A Mini Review on the Phytochemistry, Toxicology and Antiviral Activity of Some Medically Interesting Zingiberaceae Species
Clement M. Mbadiko
Department of Biology, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo.
Clement L. Inkoto
Department of Biology, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo.
Benjamin Z. Gbolo
Department of Biology, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo and Department of Basic Sciences, Faculty of Medicine, University of Gbado-Lite, P.O.Box 111, Gbado-Lite, D.R. Congo.
Emmanuel M. Lengbiye
Department of Biology, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo.
Jason T. Kilembe
Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo.
Aristote Matondo
Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo.
Domaine T. Mwanangombo
Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo.
Etienne M. Ngoyi
Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo.
Gedeon N. Bongo
Department of Biology, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo and Department of Basic Sciences, Faculty of Medicine, University of Gbado-Lite, P.O.Box 111, Gbado-Lite, D.R. Congo.
Clarisse M. Falanga
Department of Biology, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo.
Damien S. T. Tshibangu
Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo.
Dorothée D. Tshilanda
Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo.
Koto-te-Nyiwa Ngbolua
Department of Biology, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo and Department of Basic Sciences, Faculty of Medicine, University of Gbado-Lite, P.O.Box 111, Gbado-Lite, D.R. Congo.
Pius T. Mpiana *
Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, D.R. Congo.
*Author to whom correspondence should be addressed.
Abstract
Background: Plants of the Zingiberaceae family namely Curcuma longa, Aframomum melegueta and Zingiber officinale are known for their many biological activities such as the antiviral activity.
Aim: To provide an updated knowledge on the phytochemistry, toxicology and antiviral activity of some medically interesting Zingiberaceae species.
Study Design: Multidisciplinary advanced bibliographic surveys and dissemination of the resulted knowledge.
Results: The literature review shows that these edible plants have antiviral properties on different types of viruses ( Rhinovirus, hepatitis B and C viruses, Herpes simplex viruses type 1 and 2, Human immunodeficiency viruse, Enterovirus 71, Ebola Virus, Human cytomegalovirus, Chikungunya virus, Epstein-Barr Virus, Japanese Encephalitis Virus, Respiratory syncytial virus, Fish viral hemorrhagic septicemia virus, Influenza A virus, Epstein-Barr virus, Coronavirus SARS-CoV-1, etc.). In addition, the literature indicated that these plants are a significant source of nutrients, which can boost the immune system and are safe according to the existing toxicological data.
Conclusion: The present mini-review can therefore help to inform future scientific research towards the development of antiCovid-19 herbal drugs of relevance as well as nutraceuticals from these three plants species for the improvement of human health and wellbeing using reverse pharmacology approach. Molecular docking of some naturally occurring isolate compounds against SARS-CoV-2 proteases is in progress.
Keywords: Curcuma longa, Aframomum melegueta, Zingiber officinale, antiviral activity, Covid-19