Preliminary Phytochemical Screening of Five Plants as Possible Antileishmaniasis Control Agent
Journal of Complementary and Alternative Medical Research,
Leishmaniasis is a major public health problem globally and manifests in three clinical forms including visceral cutaneous and mucocutaneous. Visceral leishmaniasis is fatal if left untreated for a period of 2 years, while cutaneous leishmaniasis cause crusted papules or ulcers on exposed skin. Plant families containing active compounds against other protozoan diseases may be suitable against leishmania parasites. This study report the compounds extracted from five plants (Olea europaea, Kigelia Africana, Terminalia mollis, Croton macrostachyus and Bridella micrantha extracts). The plants were collected from Baringo County in Kenya and authenticated at the National Museums of Kenya (Department of Botany). The plant samples were dried, pulverized into fine powders and extracted using methanol at the Center for Traditional Medicine and Drugs Research, KEMRI. The plant extracts contained varying amounts of phytochemical compounds such as tannins, phenols, flavonoids, steroids, alkaloids, saponins, anthraquinone, cardiac glycoside, polyphenols, cumarins, anthocyanins, trepenoids, glycosides and triterpenoids. The presence of tannins, flavanoids, alkaloids and saponins with known biological activities offer opportunity to test these compounds against leishmania parasites.
- leishmania parasites
- phytochemical screening
- active compounds
- plant extracts.
How to Cite
Tabbabi A. Review of Leishmaniasis in the Middle East and North Africa. African Health Sciences. 2019;19(1):1329-1337.
Berger S. Cutaneous and Mucosal Leishmaniasis: Global Status: GIDEON Informatics Inc; 2018.
Hashiguchi Y, Gomez EA. Importance of Leishmania species and vector sand fly (diptera: psychodidae) identification. Journal of Medical Entomology; 2018.
Lopes JV, Michalsky EM, Pereira NC, et al. Entomological studies in Itaúna, Brazil, an area with visceral leishmaniasis transmission: Fauna survey, natural leishmania infection, and molecular characterization of the species circulating in phlebotomine sand flies (diptera: psychodidae). Journal of Medical Entomology. 2019;56(5):1368-1376.
Hepburn NC. Cutaneous leishmaniasis: An overview. Journal of Postgraduate Medicine. 2003;49(1):50.
Chappuis F, Sundar S, Hailu A, et al. Visceral leishmaniasis: What are the needs for diagnosis, treatment and control? Nature Reviews Microbiology. 2007;5(11):873-882.
Croft SL, Chatelain E, Barrett MP. Antileishmanial and antitrypanosomal drug identification. Emerging Topics in Life Sciences. 2017;1(6):613-620.
Sundar S, Chakravarty J, Meena LP. Leishmaniasis: Treatment, drug resistance and emerging therapies. Expert Opinion on Orphan Drugs. 2019;7(1):1-10.
Hendrickx S, Caljon G, Maes L. Need for sustainable approaches in antileishmanial drug discovery. Parasitology Research. 2019;118(10):2743-2752.
Parsaei P, Karimi M, Mardani M. A review of treatments for leishmaniasis wound using the prescriptions of traditional medicine. International Journal of Advanced Biotechnology and Research. 2017;8:2050-2058.
de Oliveira RM, de Araújo Melo S, da Penha-Silva TA, Almeida-Souza F, Abreu-Silva AL. Alternative Treatment for Leishmaniasis. Leishmaniases as Reemerging Diseases. 2018;145.
Al-Hajj MMA, Al-Shamahy HA, Alkhatib BY, Moharram BA. In vitro anti-leishmanial activity against cutaneous leishmania parasites and preliminary phytochemical analysis of four yemeni medicinal plants. Universal J. Pharm Res. 2018;3:48-54.
Zeouk I, Et-Touys A, Balouiri M, Fellah H, Lalami AEO, Bekhti K. Leishmanicidal activity of plant extracts from sefrou, a Moroccan focus of Leishmaniasis, against various leishmania parasites in the promastigote stage. Phytothérapie. 2019; 17(2):83-89.
Shamsi M, Abbasi N, Mohajer A, Hoseini M, Rafieian-Kopaei M. The most important native medicinal plants effective against cutaneous leishmaniasis in mouse. International Journal of Life Science and Pharma Research. 2018;8(2): P1-P7.
Minho AP, Domingues LF, Gainza YA, et al. In vitro screening of plant extract on Haemonchus contortus and rhipicephalus (Boophilus) microplus. Journal of Essential Oil Research. 2020;32(3):269-278.
Mahmoud A, Mäser P, Kaiser M, Hamburger M, Khalid S. Screening of selected sudanese medicinal plants for in vitro activity against protozoal neglected tropical diseases. Planta Medica International Open. 2017;4(S01):Tu-PO-129.
Njau VN, Maina EN, Anjili CO, et al. In vitro antileishmanial activity and phytochemical analysis of Carissa edulis against leishmania major. African Journal of Pharmacology and Therapeutics. 2017; 5(4).
Maina EN, Njau VN, Gavamukulya Y. Phytochemical analysis and anti-leishmanial activity of Clerodendrum myricoides and Salvadora persica plant extracts against leishmania major. Journal of Complementary and Alternative Medical Research. 2020;29-44.
Altemimi A, Lakhssassi N, Baharlouei A, Watson DG, Lightfoot DA. Phytochemicals: Extraction, isolation, and identification of bioactive compounds from plant extracts. Plants. 2017;6(4):42.
Bouyahya A, Assemian ICC, Mouzount H, et al. Could volatile compounds from leaves and fruits of Pistacia lentiscus constitute a novel source of anticancer, antioxidant, antiparasitic and antibacterial drugs? Industrial crops and products. 2019;128:62-69.
Barone CD, Zajac AM, Ferguson SM, et al. In vitro screening of 51 birdsfoot trefoil (Lotus corniculatus L.; Fabaceae) strains for anti-parasitic effects against Haemonchus contortus. Parasitology. 2019;146(6):828-836.
Et-Touys A, Fellah H, Mniouil M, et al. Screening of antioxidant, antibacterial and antileishmanial activities of Salvia officinalis L. extracts from Morocco. Microbiology Research Journal Inter-national. 2016:1-10.
Azmir J, Zaidul I, Rahman M, et al. Techniques for extraction of bioactive compounds from plant materials: A review. Journal of Food Engineering. 2013;117(4): 426-436.
Harborne A. Phytochemical methods a guide to modern techniques of plant analysis. Springer Science & Business Media; 1998.
Harborne J, Greenham J, Williams C. Phytochemical analysis. Chapman and Hall Company Ltd, London. 1973;1:5-6.
Ajayi I, Ajibade O, Oderinde R. Preliminary phytochemical analysis of some plant seeds. Res J Chem Sci. 2011;1(3):58-62.
Yadav R, Agarwala M. Phytochemical analysis of some medicinal plants. Journal of Phytology; 2011.
Angelova N, Kong HW, Van Der Heijden R, et al. Recent methodology in the phytochemical analysis of ginseng. Phytochemical Analysis: An International Journal of Plant Chemical and Biochemical Techniques. 2008;19(1):2-16.
Tristantini D, Jessica A. Determination of flavonoid content of mixed herbs extract using colorimetric method and thin layer chromatography (TLC). AIP Conference Proceedings; 2019: AIP Publishing LLC; 2019.p.030004.
Box J. Investigation of the Folin-Ciocalteau phenol reagent for the determination of polyphenolic substances in natural waters. Water Research. 1983;17(5):511-525.
Hajimehdipoor H, Shahrestani R, Shekarchi M. Investigating the synergistic antioxidant effects of some flavonoid and phenolic compounds. Research Journal of Pharmacognosy. 2014;1(3):35-40.
Hajimehdipoor H, Esmaeili S, Shekarchi M, Emrarian T, Naghibi F. Investigation of some biologic activities of Swertia longifolia Boiss. Research in Pharmaceu-tical Sciences. 2013;84(4):253.
Sunyoto T, Verdonck K, el Safi S, Potet J, Picado A, Boelaert M. Uncharted territory of the epidemiological burden of cutaneous leishmaniasis in sub-Saharan Africa—A systematic review. PLoS Neglected Tropical Diseases. 2018;12(10):e0006914.
Magalhães LG, Souza JM, Candido ACB, et al. In vitro evaluation of the leishmanicidal potential of selected plant derived extracts against Leishmania (Leishmania) amazonensis. International Journal of Complementary & Alternative Medicine. 2019;12(12).
Cortes S, Bruno de Sousa C, Morais T, Lago J, Campino L. Potential of the natural products against leishmaniasis in old world-a review of in vitro studies. Pathogens and Global Health. 2020:1-13.
Jiménez-Arellanes MA, León-Díaz R. Natural compounds and extracts from mexican medicinal plants with anti-leishmanial activity: An update. Leishmaniases as Re-emerging Diseases. 2018:163.
Iqbal K. Isolation, Identification, Evaluation and pharmacological effects Of antileishmanial compounds: University of Balochistan, Quetta; 2017.
Armah FA, Amponsah IK, Mensah AY, et al. Leishmanicidal activity of the root bark of Erythrophleum ivorense (Fabaceae) and identification of some of its compounds by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOF-MS/MS). Journal of Ethnopharmacology. 2018;211: 207-216.
Gutiérrez-Rebolledo GA, Drier-Jonas S, Jiménez-Arellanes MA. Natural compounds and extracts from Mexican medicinal plants with anti-leishmaniasis activity: An update. Asian Pacific Journal of Tropical Medicine. 2017;10(12):1105-1110.
Zeouk I, Et-Touys A, Balouiri M, Fellah H, Lalami AEO, Bekhti K. Leishmanicidal activity of plant extracts from sefrou, a Moroccan focus of leishmaniasis, against various leishmania parasites in the promastigote stage. Phytothérapie. 2019; 17(2):83-89.
Abstract View: 915 times
PDF Download: 566 times