A Mapping of Diabetes Amelioration Potency of Catharanthus roseus in Alloxan Induced Wistar Albino Rat, under the Light of Geographical Variation Based Contrast
Ismat Ara Chowdhury Koly
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka 1229, Bangladesh.
Isratul Jannat Mim
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Farhana Yesmin Peya
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Tasnia Rahman
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Redwanul Haque
Department of Pharmacy, Northern University Bangladesh, Dhanmondi, Dhaka, Bangladesh.
Md. Rafat Tahsin *
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka 1229, Bangladesh.
Ishrat Jahan
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Fahima Aktar
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Tahmina Aktar
Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh.
Jakir Ahmed Chowdhury
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Shaila Kabir
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Abu Asad Chowdhury
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Md. Shah Amran
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Context: There are many medicinal plants that are utilized in traditional remedies to treat diabetes because diabetes mellitus (DM) is a significant metabolic condition. One of these is the pharmacological herb Catharanthus roseus. In the herbal medicine system, the plant has been used to treat diabetes mellitus since ancient times.
Objective: In order to employ the plant material to treat diabetes, the current study set out to investigate the therapeutic effect of leaf extract from Catharanthus roseus as well as its safety profile.
Materials and Methods: The Catharanthus roseus extract was steeped in ethanol. Diabetes-induced rats with alloxan monohydrate were each given an ethanol extract of C. rosea. In pilot research, metformin plant extract was used in place of the widely prescribed anti-diabetic medication metformin, and it was found to be effective at lowering blood sugar levels while not causing hypoglycemia.
Results: Alloxan monohydrate was injected intraperitoneally into rats to cause diabetes at a dose of 150 mg/kg body weight, and the animals were also given ethanolic extracts of Catharanthus roseus leaves at doses of 500, 750, and 1100 mg/kg. Throughout the course of the trial, we checked the blood glucose levels of diabetic and control rats. After testing blood glucose levels, it was shown that all doses of Catharanthus roseus reduced the rats' unusually increased blood glucose levels. However, even 750 mg/kg significantly lowers blood sugar levels (p< 0.05). In our investigation, group 5 (alloxan + CR. Low Land) outperformed the other extract-treated groups. This shows that variations in geographic location may have an impact on plant ingredients and their bioactivity.
Conclusion: According to the study's findings, metformin and a leaf extract of Catharanthus roseus both relieved the pathological condition brought on by diabetes. It clearly shows that the Catharanthus roseus leaf extract has significant therapeutic potential for the treatment of diabetes.
Keywords: Catharanthus roseus, diabetes mellitus, alloxan, herbal medicine, geographic location