Relationship of Adrenaline Administration to Increased Blood Sugar Levels in Male Rattus norvegicus Rats
Achnes Pangaribuan *
Department of Internal Medicine, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia.
Frisca Ronauli Batubara
Department of Physiology, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia.
*Author to whom correspondence should be addressed.
Abstract
Stress is a condition that causes a steady state in the body to be disrupted. When a stressor hits the body, the hypothalamus will send a signal to the adrenal gland to produce catecholamine. One of the catecholamines is adrenaline. Adrenaline will increase heart muscle contraction, dilatation of blood vessels, and increase glycogenolysis and gluconeogenesis, increasing blood glucose. This experimental research with research subjects is male Rattus norvegicus, 24 weeks, 250-300 gr, and healthy. The total sample is 24 rats divided into four groups, with two groups of controls not injected with adrenaline and two groups of treatment. Each treatment group will be differentiated between fasting groups (P1) and not fasting groups (P2) and injected with adrenaline 0,6 mg/kgBB via intraperitoneal. This research uses pre-test and post-test methods to measure blood glucose levels. The one-way ANOVA result shows a significant difference (p<0,05) between the pre-test and post-test of blood glucose level.
Keywords: Adrenaline, blood glucose, stress, hormone