Journal of Complementary and Alternative Medical Research

COVID-19 is a disease caused by the SARS-CoV-2 virus. COVID-19 is divided into several clinical symptoms based on a person's experiences. In severe clinical signs of COVID-19, D –Dimer will be significantly higher. This study aims to determine D-Dimer levels in COVID-19 patients aged 45 – 70 and uses a descriptive-analytic method with a retrospective cross-sectional design. The number of samples was 198 patients whose D-Dimer levels were checked and 127 patients who received anticoagulant prophylaxis. The research samples were all medical records of patients suffering from COVID-19 aged 45 - 70 years and who had checked D-Dimer levels at RSU UKI from December 2020 to September 2021 found that 145 patients (73.2%) had normal D-Dimer levels, 53 patients (26.8%) had increased D-Dimer levels. The distribution of women were 100 patients (50.5%), and men were 98 patients (49.5%), the highest range was aged 54 - 62 years with 74 patients (37.4%), clinical symptoms were being experienced by 122 patients (61.6%), and comorbid hypertension was the most common disease with 64 patients (32.3%). A significant relationship was found between D-Dimer levels and comorbidities (p=0.04). Anticoagulant prophylaxis was given to 127 patients, with mild symptoms experienced by five patients (3.6%), moderate symptoms experienced by 73 patients (57.5%), and severe symptoms experienced by 49 patients (38.6%). However, no significant relationship was found (p=0.66) between administering anticoagulant prophylaxis and D-Dimer levels in patients with mild, moderate, or severe symptoms.