Exploring the Therapeutic Efficacy of Ethanolic Extract of Benincasa hispida in Alloxan Induced Diabetic Rats
Ikram Wahid Toha *
Department of Pharmacy, University of Chittagong, Bangladesh.
Shafia Islam Promi
Department of Pharmacy, University of Science and Technology Chittagong, Bangladesh.
Sampa Barai
Department of Clinical Pharmacy and Pharmacology, University of Asia Pacific, 74/A Green Road, Dhaka 1205, Bangladesh.
Abdullah Al Mamun
Department of Pharmacy, Islamic University, Kushtia -7003, Bangladesh
Shabira Sagir
Department of Pharmaceutical Technology, University of Asia Pacific, 74/A Green Road, Dhaka 1205, Bangladesh.
Sadia Tasnim
Department of Chemistry and Chemical Engineering, University of New Haven, United States.
Ambia khatun Sony
Department of Pharmacy, University of Asia Pacific, 74/A Green Road, Dhaka 1205, Bangladesh
Israt Jahan Rasna
Department of Botany, University of Chittagong, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Since the dawn of civilization, humans have used herbal medicine to treat medical ailments. This study seeks to evaluate the efficacy of Benincasa hispida as an anti-diabetic agent and its impact on lipid profiles. We assessed the efficacy of the anti-diabetes medication using the alloxan-induced diabetic model. Only the 900 mg/kg dosage exhibited statistically significant antidiabetic effects (p < 0.05) when compared to the 300 and 600 mg/kg dosages. Notwithstanding a slight reduction in these parameters, no groups demonstrated statistically significant results regarding HDL, LDL, and total cholesterol. The triglyceride value of 97.70 ± 7.50* yielded statistically significant results (p < 0.05). Conversely, SGPT and SGOT exhibited no statistically significant effects at dosages of 300, 600, or 900 mg/kg. Group 5 exhibited statistically significant results (p < 0.05) in the kidney function test in case of urea, with a value of 93.24 ± 9.23* after the administration of an extract at a dose of 600 mg/kg. No statistically significant results were seen in any groups concerning creatinine levels.
Keywords: Benincasa hispida, herbal medicine, antidiabetic, creatinine, Diabetes mellitus