Therapeutic Insights into Mangifera indica: Managing Diabetes and Hyperlipidemia in Alloxan-treated Rats
Somaya Jannat Shawon *
Department of Pharmacy, University of Asia Pacific, 74/A Green Road, Dhaka, Bangladesh.
Sabbir Khan
Department of Botany, University of Chittagong, Bangladesh.
Sara Rahmat
Department of Pharmacy, University of Asia Pacific, 74/A Green Road, Dhaka, Bangladesh.
Mafruza Khanam Prottasha
Department of Pharmacy, University of Asia Pacific, 74/A Green Road, Dhaka, Bangladesh.
Md Navid Rahman Nafsan
Department of Pharmacy, University of Asia Pacific, 74/A Green Road, Dhaka, Bangladesh.
Sadia Tasnim
Department of Chemistry and Chemical Engineering, University of New Haven, US.
Israt Jahan Rasna
Department of Botany, University of Chittagong, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
People have used herbal medicine for healing since the dawn of human civilization. This study investigated the antidiabetic efficacy and lipid profile of Mangifera indica. We evaluated the antidiabetic activity through the alloxan-induced diabetic model. The 750 mg/kg dosage in group 6 yielded statistically significant findings (p < 0.05) regarding antidiabetic efficacy.The group receiving a 750 mg/kg dose exhibited statistically significant outcomes for total cholesterol, HDL, and triglycerides, with results of 197.40±6.28*, 52.21±4.47*, and 101.75±3.29*, respectively (p<0.05). However, no groups demonstrated statistically significant outcomes regarding LDL and triglyceride levels, despite a decrease in these parameters in the blood following the administration of the extract. No groups exhibited statistically significant outcomes regarding SGPT and SGOT; however, the levels of these two parameters decreased in the blood following the administration of the extract. In the kidney function test, urea and creatinine levels in group 6 demonstrated statistical significance (pp < 0.05 at a dosage of 750 mg/kg, with values of 990.42 ± 4.82 and 11.70 ± 0.82, respectively.
Keywords: Mangifera indica, HDL, LDL, diabetes, herbal medicine, triglyceride