Journal of Complementary and Alternative Medical Research

Munzij-Mushil therapy, a cornerstone of Unani medicine, focuses on systemic detoxification through concoction (munzij) and purgation (mushil) to restore humoral balance and eliminate morbid substances. This systemic analysis evaluates the efficacy of Munzij-Mushil therapy across 20 published articles on the therapy and related topics and 6 published articles on the related topic of ishal, highlighting its role in chronic diseases, rheumatoid arthritis, hemiplegia, and lymphatic filariasis. Findings indicate significant improvements in biochemical markers, symptom relief, and functional recovery, particularly when combined with adjunct therapies like cupping and massage. However, research gaps persist, with limited clinical studies overall and also in exploring its preventive potential in healthy individuals and/or at different stages of disease progression. The therapy’s mechanisms—rooted in humoral modulation and oxidative stress reduction—underscore its holistic approach. Future research should investigate Munzij-Mushil therapy as a preventive regimen, assessing its impact on physiological health, temperament (mizaj), and Asbabe Sitta Zarooria (Six Essential Factors). The objective of this systematic review is to assess the effectiveness of Munzij-Mushil therapy across various studies, examining its potential to prevent, manage, and treat diverse health conditions. By synthesizing data from multiple sources, the review aims to provide an evidence-based understanding of how Munzij-Mushil therapy can contribute to modern healthcare practices. Bridging traditional Unani principles with modern evidence could enhance integrative healthcare strategies.